The influence of the thyroid gland on brain cholinesterase activity of mature rats
1970; Elsevier BV; Volume: 22; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(70)90403-8
ISSN1872-6240
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThe cholinesterase (ChE) activity of the brainin toto and regionally was studied in adult male rats following a 4-week period of treatment with 0.1% propylthiouracil (PTU), thyroidectomy (Tx), or daily subcutaneous administration of sodium-l-thyroxine (T4, 100 μg/kg). In addition resting metabolic rates of these animals were determined prior to, during and at the conclusion of the treatment interval. The data revealed that the ChE activity of the brainin toto is decreased in the adult hypothyroid rat whereas it is increased in the hypermetabolic animal. When the brain was separated into 4 regions, namely, (I) telencephalon, (II) diencephalonmesencephalon (midbrain), (III) cerebellum, and (IV) pons-medulla oblongata, PTU treatment resulted in diminished ChE activity of regions II and IV. Tx produced a decline in ChE activity of the diencephalon-mesencephalon, cerebellum, and ponsmedulla. Treatment with T4 increased the esterase activity of the telencephalic region (I) of the mature brain. These results suggest that the thyroid gland influences significantly the acetylcholine-ChE system of the mature brain. Alteration of the thyroid state of the rat exerted no significant effect on the weight of the brainin toto.
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