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Shear Field-Flow Fractionation: Theoretical Basis of a New, Highly Selective Technique

1984; Taylor & Francis; Volume: 19; Issue: 10 Linguagem: Inglês

10.1080/01496398408060666

1520-5754

J. Calvin Giddings, Susan L. Brantley,

Mineral Processing and Grinding

Abstract Abstract Shear field-flow fractionation (shear FFF) is described as an FFF system in which shear forces are responsible for migration perpendicular to flow. It is shown that a desirable configuration for shear FFF is a concentric cylinder system with one cylinder rotating. After providing the relevant theoretical framework of FFF, the equations of Shafer et al. describing shear migration are simplified and applied to the limiting case of very thin annular spaces to get tractable retention expressions. On this basis the maximum selectivity is predicted to be 3 or greater, a value considerably higher than that for any other macromolecular separation technique. This high selectivity is confirmed using an alternate shear migration theory developed by Tirrell et al. However, it is shown that shear FFF is only applicable to macromolecules of high molecular weight, perhaps ∼107 and above. It may also be applicable to globular particles.