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Transport of Xenobiotics Across the Blood-Brain Barrier

2002; American Physiological Society; Volume: 17; Issue: 6 Linguagem: Inglês

10.1152/nips.01402.2002

1548-9213

Bruno Hagenbuch, Bo Gao, Peter J. Meier,

Hemoglobinopathies and Related Disorders

Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.