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Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI

1999; Wiley; Volume: 14; Issue: 5 Linguagem: Inglês

10.1002/1531-8257(199909)14

1531-8257

Carme Junqu�, Montserrat Alegret, Frederich A. Nobbe, Francesc Valldeoriola, Roser Pueyo, Pere Vendrell, Eduardo Tolosa, Jordi Rumi�, Josep M. Mercader,

Transcranial Magnetic Stimulation Studies

Movement DisordersVolume 14, Issue 5 p. 780-789 Article Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI Carme Junqué PhD, Corresponding Author Carme Junqué PhD Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, SpainSearch for more papers by this authorMontse Alegret BA, Montse Alegret BA Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorFrederich A. Nobbe MD, Frederich A. Nobbe MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorFrancesc Valldeoriola MD, Francesc Valldeoriola MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorRoser Pueyo BA, Roser Pueyo BA Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorPere Vendrell PhD, Pere Vendrell PhD Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorEduardo Tolosa MD, Eduardo Tolosa MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorJordi Rumià MD, Jordi Rumià MD Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of BarcelonaSearch for more papers by this authorJosep Maria Mercader MD, Josep Maria Mercader MD Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, SpainSearch for more papers by this author Carme Junqué PhD, Corresponding Author Carme Junqué PhD Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, SpainSearch for more papers by this authorMontse Alegret BA, Montse Alegret BA Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorFrederich A. Nobbe MD, Frederich A. Nobbe MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorFrancesc Valldeoriola MD, Francesc Valldeoriola MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorRoser Pueyo BA, Roser Pueyo BA Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorPere Vendrell PhD, Pere Vendrell PhD Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Search for more papers by this authorEduardo Tolosa MD, Eduardo Tolosa MD Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPSSearch for more papers by this authorJordi Rumià MD, Jordi Rumià MD Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of BarcelonaSearch for more papers by this authorJosep Maria Mercader MD, Josep Maria Mercader MD Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, SpainSearch for more papers by this author First published: 16 January 2001 https://doi.org/10.1002/1531-8257(199909)14:5 3.0.CO;2-GCitations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3-month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive-compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right-sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes. Citing Literature Volume14, Issue5September 1999Pages 780-789 RelatedInformation