Produção Nacional
Revisado por pares
White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats
2010; BioMed Central; Volume: 61; Issue: 1 Linguagem: Inglês
10.1007/s12576-010-0122-y
ISSN1880-6562
AutoresAllain Amador Bueno, Carlos Alexandre Habitante, Lila Missae Oyama, Débora Estadella, Eliane Beraldi Ribeiro, Cláudia Maria Oller do Nascimento,
Tópico(s)Adipokines, Inflammation, and Metabolic Diseases
ResumoThe effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, EPI, liver, brown adipose tissue (BAT), blood and carcass were obtained and analyzed. Seven days following surgery, liver lipogenesis rate and EPI relative weight were increased in L. After 30 days, L, RET and EPI presented increased lipogenesis, lipolysis and percentage of small area adipocytes. L rats also presented increased liver malic enzyme activity, BAT lipogenesis, and triacylglycerol and corticosterone serum levels. The partial removal of visceral fat pads affected the metabolism of high fat diet obese rats, which leads to excised tissue re-growth and possibly compensatory growth of non-excised depots at a later time.
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