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Bone Marrow Transplants from Unrelated Donors for Patients with Chronic Myeloid Leukemia

1998; Massachusetts Medical Society; Volume: 338; Issue: 14 Linguagem: Inglês

10.1056/nejm199804023381405

1533-4406

John A. Hansen, Theodore A. Gooley, Paul J. Martin, Frederick R. Appelbaum, Thomas R. Chauncey, Reginald A. Clift, Effie W. Petersdorf, Jerald P. Radich, Jean E. Sanders, Rainer Storb, Keith M. Sullivan, Claudio Anasetti,

Eosinophilic Disorders and Syndromes

Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants from unrelated donors is an option for the 70 percent of patients without an HLA-identical sibling, but the morbidity and mortality associated with such transplants have been cause for concern. We analyzed the safety and efficacy of transplants from unrelated donors for the treatment of chronic myeloid leukemia and identified variables that predict a favorable outcome.