The current state of renal cell carcinoma grading
1997; Wiley; Volume: 80; Issue: 5 Linguagem: Inglês
10.1002/(sici)1097-0142(19970901)80
ISSN1097-0142
Autores Tópico(s)Cancer Genomics and Diagnostics
ResumoBACKGROUND The grading of renal cell carcinoma (RCC) has a long history. Currently, there are several grading systems in use throughout the world. There is no consensus regarding which grading system is optimal. METHODS A review of the patient outcome cutpoints of several RCC grading systems was conducted to determine the advantages and disadvantages of the different systems. RESULTS Almost all authors who have conducted studies of RCC grading agree that it is useful in determining prognosis. The patient outcome cutpoints vary among studies, depending on which grading system is used. Different patient outcome cutpoints have been obtained with the same grading system but different patient groups. CONCLUSIONS The ideal RCC grading system has yet to be developed. Any new grading system should be predicated on a study that has separated RCC into the new genetically based subtypes. A new system should also be based on patient outcome, be large enough to account for other prognostic parameters, and be based on reproducible histologic criteria that are easy to apply. Cancer 1997; 80:977-80. © 1997 American Cancer Society.
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