Phenolic compounds and plant extracts as potential natural anti-obesity substances
2012; Elsevier BV; Volume: 135; Issue: 1 Linguagem: Inglês
10.1016/j.foodchem.2012.04.074
ISSN1873-7072
AutoresThérèse Sergent, Jessica Vanderstraeten, Julie Winand, Pauline Béguin, Yves‐Jacques Schneider,
Tópico(s)Pharmacology and Obesity Treatment
ResumoOne strategy to prevent obesity could consist in the inhibition of the pancreatic lipase (PL). In an attempt to find natural antiobesity agents, phenolic compounds (PCs) and plant extracts were investigated on PL activity. Epigallocatechin-3-gallate > kaempferol and quercetin were detected as potent PL inhibitors, with ICs50 of 0.8, 13.4 and 21.5 μM, respectively. Plant extracts from green tea and grape seed also shown potent inhibitory effect. Selected PCs were then assayed in an in vitro model of simulated intestinal fat digestion, based on the lipolysis of triolein. In such conditions closer to physiological reality, resveratrol, but also epigallocatechin-3-gallate and quercetin reduced the triolein digestion to ±50%. This could delay or decrease in vivo fatty acid absorption by enterocytes. This work therefore suggests that some PCs, at concentrations easily reached in the intestine following ingestion of tea beverages, fruits or vegetables, but also flavonoid-enriched supplements or functional food, are potential candidates for obesity prevention.
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