Aurantimycins, New Depsipeptide Antibiotics from Streptomyces aurantiacus IMET 43917 Production, Isolation, Structure Elucidation, and Biological Activity.
1995; Springer Nature; Volume: 48; Issue: 2 Linguagem: Inglês
10.7164/antibiotics.48.119
ISSN1881-1469
AutoresU. Gräfe, R. Schlegel, M. RITZAU, W. Ihn, K. Dornberger, Cornelia Stengel, W. F. Fleck, W Gutsche, A Härtl, E. Paulus,
Tópico(s)Synthesis and Biological Activity
ResumoAurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells.
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