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Nuclear changes in apoptosis

1995; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês

10.1016/0955-0674(95)80088-3

1879-0410

William C. Earnshaw,

RNA Interference and Gene Delivery

Specific proteinases of the Ced-3/interleukin-1β converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.