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BIBTEX RIS

Amino acid sequence elucidation of human acrosin‐trypsin inhibitor (HUSI‐II) reveals that Kazal‐type proteinase inhibitors are structurally related to β‐subunits of glycoprotein hormones

1990; Wiley; Volume: 270; Issue: 1-2 Linguagem: Inglês

10.1016/0014-5793(90)81273-q

ISSN

1873-3468

Autores

Edwin Fink, Christa Hehlein-Fink, Manfred Eulitz,

Tópico(s)

Regulation of Appetite and Obesity

Resumo

The amino acid sequence of the acrosin‐trypsin inhibitor HUSI‐II from human seminal plasma is presented which unequivocally identifies HUSI‐II as being of Kazal‐type. In addition, the HUSI‐II sequence shows a striking similarity to the middle part of glycoprotein hormone β‐subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal‐type inhibitors and glycoprotein hormones.

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