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Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

2009; Royal Society of Chemistry; Issue: 41 Linguagem: Inglês

10.1039/b912784d

1364-548X

W. Mei Kok, Denis B. Scanlon, John A. Karas, Luke A. Miles, Deborah J. Tew, Michael W. Parker, Kevin J. Barnham, Craig A. Hutton,

Supramolecular Self-Assembly in Materials

Covalently cross-linked homodimeric Aβ peptides have been prepared by solid-phase peptide synthesis by exploiting 'site–site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.