X-Ray crystal structure and absolute configuration of the fungal phenalenone herqueinone
1980; Royal Society of Chemistry; Issue: 22 Linguagem: Inglês
10.1039/c39800001051
ISSN2050-5639
AutoresAndrew Quick, Robert Thomas, David Williams,
Tópico(s)Cancer Treatment and Pharmacology
ResumoThe relative and absolute configurations of the two chiral centres of herqueinone (3) have been determined by X-ray crystallographic analysis; a biosynthetic mechanism is proposed for the formation of the centre at C(2′) the stereospecificity of which is predetermined by the configuration of an intermediate containing an inverted isoprene unit at a transitory C(5) chiral centre.
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