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BIBTEX RIS

Fructose-1,6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell

2013; Elsevier BV; Volume: 720; Issue: 1-3 Linguagem: Inglês

10.1016/j.ejphar.2013.09.067

1879-0712

Fernanda Cristina de Mesquita, Shanna Bitencourt, Eduardo Caberlon, Gabriela Venturini, Bruno Souza Basso, Júlia Schmid, Gabriela A. Ferreira, Fernanda dos Santos de Oliveira, Jarbas Rodrigues de Oliveira,

Diet, Metabolism, and Disease

Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and inhibition of fibrogenic molecules are potential strategies to block HSC activation and differentiation. Aware that the process of hepatic fibrosis involves inflammatory mediators, various anti-inflammatory substances have been studied in an attempt to revert fibrosis. The purpose of this study was to investigate the in vitro effects of fructose-1,6-bisphosphate (FBP) on HSC phenotype reversion. The results demonstrated that FBP induced quiescent phenotype in GRX cells via PPARγ activation. Significant decrease in type I collagen mRNA expression was observed in the first 24 h of treatment. These events preceded the reduction of TGF-β1 and total collagen secretion. Thus, FBP promoted downregulation of HSC activation by its antifibrotic action. These findings demonstrate that FBP may have potential as a novel therapeutic agent for the treatment of liver fibrosis.