Portal de Periódicos da CAPES

Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogues

2011; American Chemical Society; Volume: 133; Issue: 36 Linguagem: Inglês

10.1021/ja206229y

1943-2984

Dmitry Tsvelikhovsky, Stephen L. Buchwald,

Catalytic C–H Functionalization Methods

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.