Decreased sulphur aminoacid intake in ulcerative colitis
1998; Elsevier BV; Volume: 351; Issue: 9115 Linguagem: Inglês
10.1016/s0140-6736(05)61120-8
ISSN1474-547X
Autores Tópico(s)Viral gastroenteritis research and epidemiology
ResumoDietary measures are not widely accepted as a form of therapy for ulcerative colitis, although withdrawal of milk has been shown to be of benefit.1 Recent evidence has implicated fermentative formation of sulphide in the disease process 2 Pitcher MCL Cummings JH Hydrogen sulphide a bacterial toxin in ulcerative colitis?. Gut. 1996; 59: 1-4 Crossref Scopus (219) Google Scholar , 3 Roediger WEW Moore J Babidge W Colonic sulfide in the pathogenesis and treatment of ulcerative colitis. Dig Dis Sci. 1997; 42: 1571-1579 Crossref PubMed Scopus (241) Google Scholar . Excess bacterial formation of sulphide in the colonic lumen or failure of detoxification of sulphide in the colonic mucosa could result in damage to colonic epithelial cells, leading to inflammation. The chief sources of sulphur for colonic fermentation and cellular function are the sulphur aminoacids (SAAs) of animal and plant origin. 3 Roediger WEW Moore J Babidge W Colonic sulfide in the pathogenesis and treatment of ulcerative colitis. Dig Dis Sci. 1997; 42: 1571-1579 Crossref PubMed Scopus (241) Google Scholar , 4 Magee EAM Cummings JH Fecal sulfide levels generated in response to changes in oral meat intake. Gastroenterology. 1997; 112: A891 Google Scholar A pilot study was undertaken to observe whether reduction of intake of SAAs would benefit patients with ulcerative colitis. Treatment with salazopyrin/prednisolone was not changed.
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