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BIBTEX RIS

Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs

2013; Public Library of Science; Volume: 8; Issue: 5 Linguagem: Inglês

10.1371/journal.pone.0064056

ISSN

1932-6203

Autores

Vanessa Ramos Faria Sea, Ana Cecília Ribeiro Cruz, Ricardo Queiroz Gurgel, Bruno Tardelli Diniz Nunes, Eliana Vieira Pinto Silva, Silvio Santana Dolabella, Roseli La Corte dos Santos,

Tópico(s)

Viral Infections and Vectors

Resumo

We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.

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