A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp 3 )–H/C(sp 2 )–H functionalizations
2014; Royal Society of Chemistry; Volume: 12; Issue: 31 Linguagem: Inglês
10.1039/c4ob01256a
ISSN1477-0539
AutoresZhiqiang Zhu, Tiantian Wang, Peng Bai, Zhi‐Zhen Huang,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoA cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines has been developed through dual C(sp3)–H/C(sp2)–H functionalizations. The synthetic method has the advantages of high yields, good compatibility of functional groups and mild reaction conditions, although very unreactive alkanes were involved in the reaction. A plausible mechanism through both copper-catalyzed and DTBP mediated pathways has also been proposed.
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