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Percutaneous venovenous Perfusion-Induced systemic hyperthermia for lung cancer: a phase I safety study

2004; Elsevier BV; Volume: 77; Issue: 6 Linguagem: Inglês

10.1016/j.athoracsur.2003.10.111

1552-6259

Joseph B. Zwischenberger, Roger A. Vertrees, Eric A. Bedell, Christopher McQuitty, Jill M Chernin, Lee C. Woodson,

Ultrasound and Cavitation Phenomena

Veno-venous perfusion-induced systemic hyperthermia (VV-PISH) homogeneously raises core body temperature potentially improving outcomes from metastatic lung cancer.Patients (n = 10) with stage IV lung cancer, received VV-PISH (>or= 42 degrees C to or= 70. Time to target temperature was 47 +/- 2 minutes, as electrolytes remained normal, without patient or circuit complications. Extubation occurred between 6 and 18 hours. Hospital stay was 4.6 +/- 1.1 days; median length-of-survival after hyperthermia was 271 days. For concurrent controls (n = 16, stage IV lung cancer), median length-of-survival from time of diagnosis to death was 96 days, but for the VV-PISH patients it was significantly longer at 450 days (p < 0.05). All patients returned to pretreatment status following treatment and died from progression of lung cancer.Venovenous perfusion-induced systemic hyperthermia is safe, technically feasible, and achieves target temperature. Survival may be enhanced in stage IV lung cancer.