Getting to the Heart of the Matter
2015; Lippincott Williams & Wilkins; Volume: 116; Issue: 7 Linguagem: Inglês
10.1161/circresaha.116.305381
ISSN1524-4571
Autores Tópico(s)Biomarkers in Disease Mechanisms
ResumoFibrotic diseases are a significant global burden for which there are limited treatment options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly contractile cell type characterized by the appearance of α-smooth muscle actin stress fibers. The underlying mechanism behind myofibroblast differentiation and persistence has been under much investigation and is known to involve a complex signaling network involving transforming growth factor-β, endothelin-1, angiotensin II, CCN2 (connective tissue growth factor), and platelet-derived growth factor. This review addresses the contribution of these signaling molecules to cardiac fibrosis.
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