Highly Enantioselective Hydrogen‐Transfer Reductive Amination: Catalytic Asymmetric Synthesis of Primary Amines
2003; Wiley; Volume: 42; Issue: 44 Linguagem: Inglês
10.1002/anie.200352503
ISSN1521-3773
AutoresRenat Kadyrov, Thomas H. Riermeier,
Tópico(s)Surface Chemistry and Catalysis
ResumoAmmonium formate is the hydrogen source in the catalytic asymmetric reductive amination of ketones presented here (Leuckart–Wallach-type reaction). The reaction proceeds smoothly in methanol in the presence of Ir, Rh, and Ru catalysts. Primary amines were obtained as products in good yields with high enantioselectivities after hydrolytic workup when [((R)-tol-binap)RuCl2] was used as the catalyst (see scheme). R1, R2=alkyl, aryl.
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