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Metal(II)–ligand molar ratio dependence of enantioseparation of tartaric acid by ligand exchange CE with Cu(II) and Ni(II)– D ‐quinic acid systems

2010; Wiley; Volume: 31; Issue: 6 Linguagem: Inglês

10.1002/elps.200900596

1522-2683

Shuji Kodama, Sen‐ichi Aizawa, Atsushi Taga, Tomohisa Yamashita, Tomoko Kemmei, Kentaro Suzuki, Yoshitaka Honda, Atsushi Yamamoto,

Chemical and Physical Properties in Aqueous Solutions

Enantioseparation of tartaric acid by ligand exchange CE with a Cu(II)-D-quinic acid system was studied. Racemic tartaric acid was enantioseparated by ligand exchange CE using BGEs containing relatively low Cu(II)-D-quinic acid molar ratios ranging from 1:1 to 1:3 and high molar ratios ranging from 1:8 to 1:12 but was not enantioseparated using BGEs with medium molar ratios ranging from 1:4 to 1:6. While the migration order of D-tartaric acid was prior to L-tartaric acid at the lower Cu(II)-D-quinic acid molar ratios, the enantiomer migration order was reversed at the higher molar ratios. These results were compared with those for Ni(II)-D-quinic acid system. The molar ratio dependence of enantiomer migration order can be attributed to a change in the coordination structure of Cu(II) ion with D-quinic acid.