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The preparation, toxicity, and clinical evaluation of 1-(2-Chloroethylthio)-2(2-Hydroxyethylthio)Ethane (Hemisesquisulfur mustard)

1957; Wiley; Volume: 10; Issue: 5 Linguagem: Inglês

10.1002/1097-0142(195709/10)10

1097-0142

Stanley P. Kramer, Jacob I. Miller, Samuel D. Gaby, Arthur Reeves, Sidney J. Vail, Benjamin Witten, Alexander M. Rutenburg, Arnold M. Seligman,

Sulfur Compounds in Biology

CancerVolume 10, Issue 5 p. 971-975 ArticleFree Access The preparation, toxicity, and clinical evaluation of 1-(2-Chloroethylthio)-2(2-Hydroxyethylthio)Ethane (Hemisesquisulfur mustard) Stanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorSamuel D. Gaby M.D., Samuel D. Gaby M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorArthur M. Reeves A.B., Arthur M. Reeves A.B. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorSidney J. Vail A.B., Sidney J. Vail A.B. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorBenjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorAlexander M. Rutenburg M.D., Alexander M. Rutenburg M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this author Stanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorSamuel D. Gaby M.D., Samuel D. Gaby M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorArthur M. Reeves A.B., Arthur M. Reeves A.B. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorSidney J. Vail A.B., Sidney J. Vail A.B. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorBenjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorAlexander M. Rutenburg M.D., Alexander M. Rutenburg M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery, Sinai Hospital and Johns Hopkins University School of Medicine, Baltimore, Maryland; the departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; and the Chemical Research Division, Chemical Warfare Laboratories, Army Chemical Center, Edgewood, MarylandSearch for more papers by this author First published: September/October 1957 https://doi.org/10.1002/1097-0142(195709/10)10:5 3.0.CO;2-DCitations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Epstein, J.; Rosenthal, R. W., and Ess, R. J.: Use of γ-(4-nitrobenzyl)pyridine as analytical reagent for ethylenimines and alkylating agents. Anal. Chem. 27: 1435–1439, 1955. 2 Fuson, R. C., and Ziegler, J. B., Jr.: 2-Chloroethyl 2-hydroxyethyl sulfide. J. Org. Chem. 11: 510–512, 1946. 3 Litchfield, J. T., Jr., and Wilcoxon, F.: Simplified method of evaluating dose-effect experiments. J. Pharmacol. & Exper. Therap. 96: 99–113, 1949. 4 Rueggeberg, W. H. C.; Cook, W. A., and Reid, E. E.: Photosynthesis of semi-mustard gas, 2-chloroethyl-2-hydroxyethyl sulfide. J. Org. Chem. 13: 110–115, 1948. 5 Rutenburg, A. M., and Seligman, A. M.: Palliation of carcinomatosis with ascites by means of hemisulfur mustard (2-chloro-2′-hydroxydiethyl sulfide). New England J. Med. 255: 361–368, 1956. 6 Seligman, A. M.; Nachlas, M. M.; Manheimer, L. H.; Friedman, O. M., and Wolf, G.: Development of new methods for histochemical demonstration of hydrolytic intracellular enzymes in program of cancer research. Ann. Surg. 130: 333–341, 1949. 7 Seligman, A. M.; Rutenburg, A. M.; Persky, L., and Friedman, O. M.: Effect of 2-chloro-2′-hydroxydiethyl sulfide (hemisulfur mustard) on carcinomatosis with ascites. Cancer 5: 354–363, 1952. 8 Stein, W. H.; Fruton, J. S., and Bergmann, M.: Chemical reactions of mustard gas and related compounds; V, chemical reactions of 1,2-bis(β-chloroethylthio)-ethane. J. Org. Chem. 11: 692–703, 1946. Citing Literature Volume10, Issue5September/October 1957Pages 971-975 ReferencesRelatedInformation