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In vitro and in vivo antifungal activities of BMS-181184.

1992; Springer Nature; Volume: 45; Issue: 9 Linguagem: Inglês

10.7164/antibiotics.45.1512

1881-1469

TOSHIKAZU OKI, Masatoshi Kakushima, Minoru Hirano, Akiyo Takahashi, Akemi Ohta, SHINJI MASUYOSHI, Masami Hatori, Hideo Kamei,

Nail Diseases and Treatments

BMS-181184 is a water-soluble pradimicin derivative with a broad antifungal spectrum in vitro and demonstrable efficacy against systemic infections with Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus in normal and cyclophosphamide-treated immunosuppressed mice.