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Increase of lifespan for glioma-bearing rats by using minibeam radiation therapy

2011; Wiley; Volume: 19; Issue: 1 Linguagem: Inglês

10.1107/s0909049511047042

1600-5775

Yolanda Prezado, Sukhéna Sarun, Sílvia Gil, Pierre Deman, Audrey Bouchet, Géraldine Le Duc,

Effects of Radiation Exposure

This feasibility work assesses the therapeutic effectiveness of minibeam radiation therapy, a new synchrotron radiotherapy technique. In this new approach the irradiation is performed on 9L gliosarcoma-bearing rats with arrays of parallel beams of width 500-700 µm. Two irradiation configurations were compared: a lateral unidirectional irradiation and two orthogonal arrays interlacing at the target. A dose escalation study was performed. A factor of three gain in the mean survival time obtained for some animals paves the way for further exploration of the different possibilities of this technique and its further optimization.