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P-TSA Catalyzed Facile and Efficient Synthesis of Polyhydroquinoline Derivatives through Hantzsch Multi-Component Condensation

2008; Pharmaceutical Society of Japan; Volume: 56; Issue: 7 Linguagem: Inglês

10.1248/cpb.56.1002

1347-5223

Sanjeeva Reddy Cherkupally, Raghu Vardhan Reddy Mekala,

Phenothiazines and Benzothiazines Synthesis and Activities

A facile and efficient synthetic route to polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of p-toluenesulfonic acid (p-TSA) catalyst in ethanol at ambient temperature through Hantzsch reaction. Simple work-up procedure, environmentally friendly, inexpensive and non-toxic catalyst, shorter reaction times along with excellent product yields are the significant features of this practical method.