Portal de Periódicos da CAPES

T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

1998; Elsevier BV; Volume: 19; Issue: 10 Linguagem: Inglês

10.1016/s0167-5699(98)01326-7

1355-8242

Konstantin V. Salojin, Jian Zhang, Joaquı́n Madrenas, Terry L. Delovitch,

Atherosclerosis and Cardiovascular Diseases

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.