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Poly(vinylidene-trifluoroethylene)/barium titanate composite for in vivo support of bone formation

2013; SAGE Publishing; Volume: 29; Issue: 1 Linguagem: Inglês

10.1177/0885328213515735

1530-8022

Helena Bacha Lopes, Thiago de Santana Santos, Fabiola S de Oliveira, Gileade Pereira Freitas, Adriana LG de Almeida, Rossano Gimenes, Adalberto Luiz Rosa, Márcio Mateus Beloti,

Bone and Dental Protein Studies

In this study, we evaluated the effect of poly(vinylidene fluoride-trifluoroethylene)/barium titanate (P(VDF-TrFE)/BT) membrane on in vivo bone formation. Rat calvarial bone defects were implanted with P(VDF-TrFE)/BT and polytetrafluoroethylene (PTFE) membranes, and at 4 and 8 weeks, histomorphometric and gene expression analyses were performed. A higher amount of bone formation was noticed on P(VDF-TrFE)/BT compared with PTFE. The gene expression of RUNX2, bone sialoprotein, osteocalcin, receptor activator of nuclear factor-kappa B ligand, and osteoprotegerin indicates that P(VDF-TrFE)/BT favored the osteoblast differentiation compared with PTFE. These results evidenced the benefits of using P(VDF-TrFE)/BT to promote new bone formation, which may represent a promising alternative to be employed in guided bone regeneration.