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Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth

2008; Elsevier BV; Volume: 367; Issue: 2 Linguagem: Inglês

10.1016/j.bbrc.2007.12.091

1090-2104

Yukiteru Ouji, Masahide Yoshikawa, Kei Moriya, Mariko Nishiofuku, Ryosuke Matsuda, Shigeaki Ishizaka,

Nerve injury and regeneration

Although Wnts are expressed in hair follicles throughout life from embryo to adult, and considered to be critical for their development and maturation, their roles remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, Wnt-5a, Wnt-10b, and Wnt-11) on epithelial cell differentiation using adult mouse-derived primary skin epithelial cell (MPSEC) cultures and hair growth using hair follicle organ cultures. Only Wnt-10b showed evident promotion of epithelial cell differentiation and hair shaft growth, in contrast to Wnt-3a, 5a, and 11. Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle.