The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014; Elsevier BV; Volume: 54; Issue: 2 Linguagem: Inglês
10.1016/j.molcel.2014.03.040
ISSN1097-4164
AutoresXin Cai, Yu‐Hsin Chiu, Zhijian J. Chen,
Tópico(s)Mosquito-borne diseases and control
ResumoThe innate immune system deploys a variety of sensors to detect signs of infection. Nucleic acids represent a major class of pathogen signatures that can trigger robust immune responses. The presence of DNA in the cytoplasm of mammalian cells is a danger signal that activates innate immune responses; however, how cytosolic DNA triggers these responses remained unclear until recently. In this review, we focus on the mechanism of DNA sensing by the newly discovered cGAS-cGAMP-STING pathway and highlight recent progress in dissecting the in vivo functions of this pathway in immune defense as well as autoimmunity.
Referência(s)