p38α MAPK can positively or negatively regulate Rac‐1 activity depending on the presence of serum
2007; Wiley; Volume: 581; Issue: 20 Linguagem: Inglês
10.1016/j.febslet.2007.06.078
ISSN1873-3468
AutoresSusana Zuluaga, Álvaro Gutiérrez-Uzquiza, Paloma Bragado, Alberto Álvarez, Manuel Benito, Ángel R. Nebreda, Almudena Porrás,
Tópico(s)Caveolin-1 and cellular processes
ResumoThe small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum.
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