Produção Nacional
Revisado por pares
Análise térmica aplicada à caracterização da sinvastatina em formulações farmacêuticas
2010; Brazilian Chemical Society; Volume: 33; Issue: 8 Linguagem: Inglês
10.1590/s0100-40422010000800007
ISSN1678-7064
AutoresMarcelo Antônio de Oliveira, María Irene Yoshida, Elionai Cassiana de Lima Gomes, Wagner da Nova Mussel, Cristina Duarte Vianna‐Soares, Gérson Antônio Pianetti,
Tópico(s)Drug Solubulity and Delivery Systems
ResumoIN PHARMACEUTICAL FORMULATIONS. Thermogravimetry (TG) and differential scanning calorimetry (DSC) are used in pharmaceutical studies for drugs characterization, purity, formulations compatibility, polymorphism identification, stability evaluation, and thermal decomposition of drugs and pharmaceutical formulations.Simvastatin showed fusion at 138.5 ºC and thermal stability up to 248 ºC.Simvastatin was incompatible with preservative excipient butylhydroxyanisole (BHA) performing a process of crystal amorphization.The drug showed morphological polymorphism, where it has the same unit cell but with different crystal habits according to the recrystallization solvent.
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