Experimental epileptogenesis: Kindling-induced epilepsy in rats
1978; Elsevier BV; Volume: 58; Issue: 2 Linguagem: Inglês
10.1016/0014-4886(78)90133-4
ISSN1090-2430
AutoresJohn P. J. Pinel, Louis I. Rovner,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoWhen electrical stimulation is periodically applied to any one of a number of forebrain sites, there is a progressive development and intensification of elicited motor seizures which can culminate in the development of an epileptic syndrome characterized by spontaneously recurring motor seizures; however, spontaneous motor seizures have been observed in relatively few kindled animals. In the present experiment rats received amygdaloid stimulation about 300 times during a 134-day period. The initial development and intensification of elicited clonic motor seizures progressed as others have described it; however, with continued stimulation running fits were eventually elicited in most of the subjects, and seizures with a tonic component were elicited in a few. Spontaneous motor seizures similar to those elicited by stimulation were observed in 16 of the 18 kindled subjects. Thus, rather than being an idiosyncratic response of a few kindled rats, spontaneous motor seizures appear to be a reliable manifestation of long-term amygdaloid kindling.
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