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A BrdU-enhanceable fragile site or viral modification site at 11q23.1 in lymphoblastoid cultures

1988; Karger Publishers; Volume: 47; Issue: 4 Linguagem: Inglês

10.1159/000132549

1424-8581

G.R. Sutherland, Elizabeth Baker, David F. Callen,

Parvovirus B19 Infection Studies

Chromosomes prepared from EBV-transformed lymphoblastoid cell lines show an achromatic gap or fragile sitelike lesion at llq23.1. The low spontaneous expression of this lesion is greatly enhanced by BrdU and <i>n</i>-butyric acid. The lesion was expressed homozygously in all 16 cell lines examined. It is suggested that the lesion is a viral chromosome modification site.