Choline acetyltransferase activity and [3H]quinuclidinylbenzilate binding in brains of scrapie-infected hamsters
1984; Elsevier BV; Volume: 51; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(84)90267-2
ISSN1872-7972
AutoresCarlo Masullo, Maurizio Pocchiari, Clarence J. Gibbs, D. Carleton Gajdusek,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoCholine acetyltransferase (ChAT) activity and [3H]quinuclidinylbenzilate binding were studied in the brain of scrapie-infected hamsters and sham inoculated controls. Although scrapie-infected hamsters showed no reduction of ChAT activity compared to the controls, they showed a decrease in the affinity and maximum number of post-synaptic muscarinic receptors. Scrapie virus thus alters the cholinergic system at the post-synaptic rather than at the pre-synaptic level.
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