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Structural Properties of Pore-Forming Oligomers of α-Synuclein

2009; American Chemical Society; Volume: 131; Issue: 47 Linguagem: Inglês

10.1021/ja9077599

1943-2984

Hai-Young Kim, Min‐Kyu Cho, Ashutosh Kumar, Elke Maier, Carsten Siebenhaar, Stefan Becker, Claudio O. Fernández, Hilal A. Lashuel, Roland Benz, Adam Lange, Markus Zweckstetter,

Conducting polymers and applications

Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure−toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein α-synuclein, a key player in Parkinson's disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their β-structure differs from that of amyloid fibrils of α-synuclein.