Portal de Periódicos da CAPES

Antimutagenic diterpenoids from a crude drug isodonis herba (Enmei-So).

1984; Oxford University Press; Volume: 48; Issue: 6 Linguagem: Inglês

10.1271/bbb1961.48.1647

1881-1280

Shizuko Kakinuma, Yukiko Okada, Nobuo Ikekawa, Tsuneo Kada, Masao Nomoto,

Sesquiterpenes and Asteraceae Studies

Recently trials have been carried out to detect the natural antimutagens of plant and animal sources, and to study the mechanism and implications of their action.1}Described in this paper are the results of one such screening of natural sources, in which we were able to isolate three diterpenoids as antimutagens.2)The bioassay system used was a paper disk-agar plate method, adopted from the one originally described.3)After brief irradiation with ultraviolet light, a cell suspension of the test organism Escherichia coli WP2B/r (tryptophan auxotroph) was spread on agar plates of semi-enriched (MB) medium.3)Paper disks (Toyo Filter Paper, 8mm