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Monoclonal Antibody Studies Defining the Origin and Properties of Autoantibodies in Graves' Disease

1986; Wiley; Volume: 475; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1986.tb20865.x

1749-6632

Leonard D. Kohn, Francisco V. Álvarez, Claudio Marcocci, A. D. Kohn, Daniela Corda, William E. Hoffman, Donatella Tombaccini, WILLIAM A. VALENTE, Michele De Luca, Pilar Santisteban, Evelyn F. Grollman,

Growth Hormone and Insulin-like Growth Factors

The present report summarizes experiments with monoclonal antibodies to the TSH receptor. The data provide further insight into the TSH receptor structure and into the basis of autoimmune antibodies implicated in the pathogenesis of Graves' disease. They resolve many clinical questions and provide new approaches to enhance our understanding of autoimmune disease. In one new approach, it has been noted that the 11E8 TBIAb can precipitate the phosphorylated beta subunit of the insulin and IGF1 receptor. This cross-reactivity or recognition of determinants adjacent to the TSH receptor may not be random. Insulin, IGF1, alpha 1 adrenergic, and TSH receptors have been linked to a synergistic cascade response system of the thyroid involving growth, thyroglobulin biosynthesis, iodination of thyroglobulin, and thyroid hormone formation. Future studies with the monoclonals may help unravel this cascade system and its regulatory relationships, along with the relationships between autoimmune thyroid disease and autoimmune diseases of other organs.