Changes in glycolipid expression in human testicular tumor
1990; Wiley; Volume: 45; Issue: 6 Linguagem: Inglês
10.1002/ijc.2910450610
ISSN1097-0215
AutoresChikara Οhyama, Yasuo Fukushi, Makoto Satoh, Seiichi Saito, Seiichi Orikasa, Edward Nudelman, Mark Straud, Sen‐itiroh Hakomori,
Tópico(s)RNA Interference and Gene Delivery
ResumoAbstract Glycolipids were extracted from testicular tumor tissues of 13 patients, and their pattern of expression compared with that of normal testicular tissue. The most conspicuous and consistent change in the tumor extracts was marked accumulation of CTH (ceramide trihexoside). Structural analysis by enzyme cleavage showed that CTH which accumulated in the tumor tissue was Gb 3 (Galαl‐4Galßl‐4Glcßl‐Cer). Immunohistochemistry using anti‐Gb 3 monoclonal antibody (MAb) (lA4) also indicated massive accumulation of Gb 3 in the tumor tissue. Gb 3 may be a new marker of testicular tumors, especially seminomas, for which useful markers are so far lacking.
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