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Platinum analogues in preclinical and clinical development

1993; Lippincott Williams & Wilkins; Volume: 5; Issue: 6 Linguagem: Inglês

10.1097/00001622-199311000-00011

1531-703X

Thomas C. Hamilton, Peter J. O’Dwyer, Robert F. Ozols,

Nanoparticle-Based Drug Delivery

The impact of cisplatin on chemotherapy for solid tumors has led to the synthesis of many molecules with platinum as their central building block. These so-called platinum analogues have been developed with the obvious goals of improving the antitumor activity of cisplatin and hopefully, at the same time, altering the dose-limiting side effects of the prototype drug. At least 10 such molecules are in clinical development, whereas several others are at various stages of preclinical testing.