Gender effect on apolipoprotein E 84 allele-associated risk for sporadic Alzheimer's disease
2009; Wiley; Volume: 97; Issue: 1 Linguagem: Inglês
10.1111/j.1600-0404.1998.tb00611.x
ISSN1600-0404
AutoresOnofre Combarros, C Leno, Agustı́n Oterino, José Berciano, José L. Fernández-Luna, Carlos Fernández‐Viadero, Nicolás Peña, José M. Miró, Miguel Delgado‐Rodríguez,
Tópico(s)Cholinesterase and Neurodegenerative Diseases
ResumoActa Neurologica ScandinavicaVolume 97, Issue 1 p. 68-71 Gender effect on apolipoprotein E 84 allele-associated risk for sporadic Alzheimer's disease O. Combarros, Corresponding Author O. Combarros Services of Neurology, University Hospital "Marques de Valdecilla", SantanderDr O. Combarros, Service of Neurology, University Hospital "Marques de Valdecilla", 39008 Santander, Spain Fax 42-202655Search for more papers by this authorC. Leno, C. Leno Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorA. Oterino, A. Oterino Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorJ. Berciano, J. Berciano Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorJ. L. Fernandez-Luna, J. L. Fernandez-Luna Immunology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorC. Fernandez-Viadero, C. Fernandez-Viadero Geriatric Hospital "Padre Menni", CuetoSearch for more papers by this authorN. Pena, N. Pena Geriatric Hospital "Padre Menni", CuetoSearch for more papers by this authorJ. Miró, J. Miró Community Health Center, Astillero, Santander, SpainSearch for more papers by this authorM. Delgado, M. Delgado Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cantabria, Santander, SpainSearch for more papers by this author O. Combarros, Corresponding Author O. Combarros Services of Neurology, University Hospital "Marques de Valdecilla", SantanderDr O. Combarros, Service of Neurology, University Hospital "Marques de Valdecilla", 39008 Santander, Spain Fax 42-202655Search for more papers by this authorC. Leno, C. Leno Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorA. Oterino, A. Oterino Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorJ. Berciano, J. Berciano Services of Neurology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorJ. L. Fernandez-Luna, J. L. Fernandez-Luna Immunology, University Hospital "Marques de Valdecilla", SantanderSearch for more papers by this authorC. Fernandez-Viadero, C. Fernandez-Viadero Geriatric Hospital "Padre Menni", CuetoSearch for more papers by this authorN. Pena, N. Pena Geriatric Hospital "Padre Menni", CuetoSearch for more papers by this authorJ. Miró, J. Miró Community Health Center, Astillero, Santander, SpainSearch for more papers by this authorM. Delgado, M. Delgado Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cantabria, Santander, SpainSearch for more papers by this author First published: 29 January 2009 https://doi.org/10.1111/j.1600-0404.1998.tb00611.xCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Introduction - The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial. Material and methods - ApoE allelic frequencies and the effect of apoE 4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls. Results - The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 4 alleles, were not statistically different between men and women. No effect of the dosage of the 4 allele was found on the age at onset of dementia in the 2 sex groups. Conclusion - Our data suggest that the relation of the apoE genotype to AD is not dependent on sex. Citing Literature Volume97, Issue1January 1998Pages 68-71 RelatedInformation
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