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Antiplasmodial Activity of Compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar Rain Forest

2006; Thieme Medical Publishers (Germany); Volume: 72; Issue: 15 Linguagem: Inglês

10.1055/s-2006-951729

1439-0221

Shugeng Cao, Lalasoa Ranarivelo, Michel Ratsimbason, Sennen Randrianasolo, Fidy Ratovoson, Mamisoa Andrianjafy, David G. I. Kingston,

Synthetic Organic Chemistry Methods

Bioassay-directed separation of the butanol-soluble portion of an extract of Sloanea rhodantha (Baker) Capuron var. rhodantha (Elaeocarpaceae) active against the drug-sensitive HB3 strain of Plasmodium falciparum led to the isolation of seven phenolic compounds, gallic acid (1), 3,5-di-O-galloylquinic acid (2), 1,6-di-O-galloyl glucopyranoside (3), 3,4,5-tri-O-galloylquinic acid (4), 1-O-eudesmoylquinic acid (5), 1,2,3,6-tetra-O-galloyl glucopyranoside (6), and 3,4,5-trimethoxyphenyl-(6′-O-galloyl)-O-b-D-glucopyranoside (7). The structure of the new compound 5 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. Compounds 2, 3, 4, 6, and 7 showed weak inhibitory activity against the drug-sensitive HB3 and the drug-resistant FCM29 strains of P. falciparum, with IC50 values ranging from 8.0 - 43.0 and 16.1 - 93.0 μg/mL, respectively.