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Antiviral activity of berberine and related compounds against human cytomegalovirus

2007; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês

10.1016/j.bmcl.2006.12.085

1464-3405

Kyoko Hayashi, Kazuki Minoda, Yasuo Nagaoka, Toshimitsu Hayashi, Shinichi Uesato,

Calcium signaling and nucleotide metabolism

Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 μM) of 1 was equivalent to that (IC50 0.91 μM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.