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Method for improving the accuracy of quantitative cerebral perfusion imaging

2005; Wiley; Volume: 21; Issue: 5 Linguagem: Inglês

10.1002/jmri.20305

1522-2586

Ken Sakaie, Wanyong Shin, Kenneth R. Curtin, Richard M. McCarthy, Ty A. Cashen, Timothy J. Carroll,

Traumatic Brain Injury and Neurovascular Disturbances

Abstract Purpose To improve the accuracy of dynamic susceptibility contrast (DSC) measurements of cerebral blood flow (CBF) and volume (CBV). Materials and Methods In eight volunteers, steady‐state CBV (CBV SS ) was measured using TrueFISP readout of inversion recovery (IR) before and after injection of a bolus of contrast. A standard DSC (STD) perfusion measurement was performed by echo‐planar imaging (EPI) during passage of the bolus and subsequently used to calculate the CBF (CBF DSC ) and CBV (CBV DSC ). The ratio of CBV SS to CBV DSC was used to calibrate measurements of CBV and CBF on a subject‐by‐subject basis. Results Agreement of values of CBV (1.77 ± 0.27 mL/100 g in white matter (WM), 3.65 ± 1.04 mL/100 g in gray matter (GM)), and CBF (23.6 ± 2.4 mL/(100 g min) in WM, 57.3 ± 18.2 mL/(100 g min) in GM) with published gold‐standard values shows improvement after calibration. An F‐test comparison of the coefficients of variation of the CBV and CBF showed a significant reduction, with calibration, of the variability of CBV in WM ( P < 0.001 ) and GM ( P < 0.03), and of CBF in WM ( P < 0.0001). Conclusion The addition of a CBV SS measurement to an STD measurement of cerebral perfusion improves the accuracy of CBV and CBF measurements. The method may prove useful for assessing patients suffering from acute stroke. J. Magn. Reson. Imaging 2005;21:512–519. © 2005 Wiley‐Liss, Inc.