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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Direct Asymmetric Michael Addition to Nitroalkenes: Vinylogous Nucleophilicity under Dinuclear Zinc Catalysis

2009; American Chemical Society; Volume: 131; Issue: 13 Linguagem: Inglês

10.1021/ja809723u

ISSN

1943-2984

Autores

Barry M. Trost, Julien Hitce,

Tópico(s)

Chemical Synthesis and Reactions

Resumo

Under dinuclear catalysis, the direct conjugate addition of 2(5H)-furanone to nitroalkenes involves the γ-position of the nucleophile. The synthetically versatile Michael adducts are prepared in good yields, with high levels of diastereo- and enantioselectivity. A model is presented to rationalize the observed stereoselectivity.

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