Identification and ecdysteroid antagonist activity of three resveratrol trimers (suffruticosols A, B and C) from Paeonia suffruticosa
1999; Elsevier BV; Volume: 55; Issue: 2 Linguagem: Inglês
10.1016/s0040-4020(98)01049-7
ISSN1464-5416
AutoresSatyajit D. Sarker, Pensri Whiting, Laurence Dinan, Vladimír Šik, Huw H. Rees,
Tópico(s)Sirtuins and Resveratrol in Medicine
ResumoBioassay-guided HPLC analysis of the seeds of Paeonia suffruticosa has afforded three novel resveratrol trimers (suffruticosol A, suffruticosol B and suffruticosol C), together with cis-resveratrol and paeoniflorin. The structures of these new compounds have been elucidated mainly by comprehensive 1D- and 2D-NMR experiments. Resveratrol and its oligomers are active as ecdysteroid antagonists (ED50 values = 10 to 50 μM vs. 5 × 10−8M 20-hydroxyecdysone) in the Drosophila melanogaster BII bioassay. The activities of other "pseudo-oestrogens" in this bioassay have also been assessed.
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