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Keloids: Etiology, and Management by Excision and Intensive Prophylactic Radiation

1959; American Medical Association; Volume: 80; Issue: 6 Linguagem: Inglês

10.1001/archderm.1959.01560240124013

1538-3652

Harry L. Arnold,

Genetic and rare skin diseases.

Julius Jadassohn's classification of keloids into the "true" (spontaneous) and "false" (traumatic) variety 1 would seem unduly meticulous to modern dermatologists, but most of them would still subscribe to his statement that excision followed by irradiation is the treatment of choice. Flurries of interest in such procedures as infiltration with hyaluronidase, corticotropin (ACTH), and hydrocortisone; freezing; dermabrasion, and others have ended largely in disappointment. Little has been published since Belisario's detailed review of the literature in 1957 2 (except for Kelley and Pinkus's article on tetrahydroxyquinone, which is mainly for inoperable cases 3 ) to warrant special mention here. In Belisario's series of 114 lesions, excision and irradiation preceded by infiltration with hyaluronidase (150 units per ml.), hydrocortisone (25 mg. per ml.), or both, gave better results than excision and irradiation alone. Of 30 cases treated in this way, 17 achieved a cosmetically sat