The role of alveolar macrophages and dendritic cells in allergic airway sensitization
1996; Wiley; Volume: 51; Issue: 5 Linguagem: Inglês
10.1111/j.1398-9995.1996.tb04611.x
ISSN1398-9995
Autores Tópico(s)Food Allergy and Anaphylaxis Research
ResumoAllergyVolume 51, Issue 5 p. 279-292 Free Access The role of alveolar macrophages and dendritic cells in allergic airway sensitization H. M. Jansen, H. M. Jansen Department of Pulmonology, Room F4206 Academic Medical Center Meibergdreef 9 1105 AZ Amsterdam The NetherlandsSearch for more papers by this author H. M. Jansen, H. M. Jansen Department of Pulmonology, Room F4206 Academic Medical Center Meibergdreef 9 1105 AZ Amsterdam The NetherlandsSearch for more papers by this author First published: May 1996 https://doi.org/10.1111/j.1398-9995.1996.tb04611.xCitations: 16AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Lawerijns JM, Baert JH. Alveolar clearance and the role of pulmonary lymphatics. Am Rev Respir Dis 1977; 115: 625– 48. 2 Holt PG. Regulation of antigen presenting cell function (s) in lung and airway tissues. Eur Respir J 1993; 6: 120– 9. 3 McMenamin C., Girn B., Holt PG. The distribution of IgE plasma cells in lymphoid and non-lymphoid tissues of high-lgE responder rats: differential localization of antigen-specific and "bystander" components of the IgE response to inhaled antigen. Immunology 1992; 77: 592– 6. 4 Holt PG, Sedgwick JD. Suppression of IgE responses following inhalation of antigen. A natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today 1987; 8: 14– 16. 5 Sedgwick JD, Holt PG. Down regulation of immune responses to inhaled antigen: studies on the mechanisms of induced suppression. Immunology 1985; 56: 635– 9. 6 Holt PG, Clough JB, Holt BJ, et al. Genetic "risk" for atopy is associated with delayed postnatal maturation of T-cell competence. Clin Exp Allergy 1992; 22: 1093– 9. 7 Wierenga EA, Snoek M., de Groot C., et al. Evidence for compartmentalization of functional subsets of CD4 + lymphocytes in atopic patients. J Immunol 1990; 1441: 4651– 6. 8 Parronchi P., Macchia D., Piccini M., et al. Allergen- and bacterial antigen-specific Tcell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci U S A 1991; 88: 4538– 42. 9 van Neerven RJJ, Van'thof W., Ringrose JH, et al. T cell epitopes of house dust mite major allergen Der p 2. J Immunol 1993; 151: 2326– 35. 10 van Neerven RJJ, van DE Pol MM, van Millingen FJ, Jansen HM, Aalberse RC, Kapsenberg ML. Characterization of cat dander-specific lymphocytes from atopic patients. J Immunol 1994; 152: 4203– 10. 11 Field EH, Noelle RJ, Rouse T., Goeken J., Waldschmidt T. Evidence for excessive Th2 CD4 + subset activity in vivo. J Immunol 1993; 151: 48– 59. 12 van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML. High frequency of IL-4-producing CD4 + allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 1991; 97: 389– 94. 13 Vercelli D., Jabara HH, Lee B., Woodland N., Geha RS, Leung DYM. Human recombinant IL-4 induces FccR2/CD23 on normal human monocytes. J Exp Med 1988; 167: 1406– 16. 14 Bieber T., Rieger A., Neuchrist C., et al. Induction of FccR2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon. J Exp Med 1989; 170: 309– 14. 15 Street NE, Schumacher JD, Fong TAT, et al. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J Immunol 1990; 144: 1629– 39. 16 Aubock J., Niederwieser D., Romani N., Fritsch P., Huber C. Human interferon-gamma induces expression of HLA-DR on keratinocytes and melanocytes. Arch Dermatol Res 1985; 277: 270– 5. 17 Gaspari AA, Katz SI. Induction and functional characterization of class II MHC (la) antigens on murine keratinocytes. J Immunol 1988; 140: 2956– 63. 18 Weller FR, de Jong MCJM, Weller MS, Heeres K., de Monchy JGR, Jansen HM. HLA-DR expression is induced on keratinocytes in delayed hypersensitivity, but not in allergen induced late-phase reactions. Clin Exp Allergy 1995; 25: 252– 9. 19 Smith DL, Deshazo RD. Bronchoalveolar lavage in asthma. An update and perspective. Am Rev Respir Dis 1993; 148: 523– 32. 20 Bice DE, Shopp GM. Antibody responses after lung immunization. Exp Lung Res 1988; 14: 133– 55. 21 Bruinier B., Krouwels FH, Hol BEA, Jansen HM, Out TA, Lutter R. Expression of activation markers by human lung T cells after adherence to lung epithelial cells. Am J Physiol (Lung Cell Mol Physiol) 1994; 267: L543– 50. 22 Holt PG, Sedgwick JD. Suppression of IgE responses following antigen inhalation: a natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today 1987; 8: 14– 15. 23 Holt PG, McMenamin C. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin Exp Allergy 1989; 19: 255– 62. 24 Holt PG, Leivers S. Tolerance induction via antigen inhalation: isotype specificity, stability and involvement of suppressor T-cells. Int Arch Allergy Appl Imniunol 1982; 67: 155– 60. 25 Sedgwick JD, Holt PG. Induction of IgE-secreting cells and IgE-isotype-specific suppressor T-cells in respiratory tract lymph nodes of rats exposed to an antigen aerosol. Cell Immunol 1985; 94: 182– 94. 26 McMenamin C., Oliver J., Girn B., Holt BJ, Kees UR, Holt PG. Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3 + TCR alpha-/beta-lymphocytes (putative gamma/delta T cells). Immunology 1991; 74: 234– 9. 27 McMenamin C., Schon-Hergard OJ, Holt PG. Regulation of IgE responses to inhaled antigens: cellular mechanisms underlying allergic sensitization versus tolerance induction. Int Arch Allergy Appl Immunol 1991; 94: 78– 81. 28 Holt PG, Vines J., Britten D. Suppression of IgE responses by antigen inhalation: failure of tolerance mechanism (s) in newborn rats. Immunology 1988; 63: 591– 3. 29 Strobel S., Ferguson A. Immune responses to fed protein antigens in mice. III. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr Res 1984; 18: 588– 94. 30 Sedgwick JD, Holt PG. Suppression of IgE responses in inbred rats by repeated respiratory tract exposure to antigen: responder phenotype influences isotype specificity of induced tolerance. Eur J Immunol 1984; 14: 893– 7. 31 Holt PG, Britten D., Sedgwick JD. Suppression of 1gE responses by antigen inhalation: studies on the role of genetic and environmental factors. Immunology 1987; 60: 97– 102. 32 Sibille Y., Reynolds H. Macrophages and polymorpho-nuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990; 14: 471– 501. 33 Nathan CF. Secretory products of macrophages. J Clin Invest 1987; 79: 319– 26. 34 Martinet Y., Yamauchi K., Crystal RG. Differential expression of tumor necrosis factor/cachectin gene by blood and lung mononuclear phagocytes. Am Rev Respir Dis 1988; 138: 659– 65. 35 Bernaudin JF, Yamauchi K., Wewers MD, Tocci MJ, Ferrans VJ, Crystal RG. Demonstration by in situ hybridization of dissimilar IL-lbeta gene expression in human alveolar macrophages and blood monocytes to lipopoly-saccharide. J Immunol 1988; 140: 3822– 9. 36 Strieter RM, Chensue SW, Basha MA. Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-alpha, lipopolysaccharide, and inter-leukin-lbeta. Am J Respir Cell Mol Biol 1990; 2: 321– 6. 37 Blusse van Oud Alblas A., van der Linden-Schrever B., van Furth R. Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intracellular administration of aerosolised heat-killed BCG. Am Rev RespirDis 1983; 128: 276– 81. 38 Dethloff LA, Lehnert BE. Pulmonary interstitial macrophages: isolation and flow cytometric comparison with alveolar macrophages and blood monocytes. J Leukoc Biol 1988; 43: 80– 90. 39 Bitterman PB, Salzman LE, Adelberg S., Ferrans VJ, Crystal RG. Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. J Clin Invest 1984; 74: 460– 9. 40 Brieland JK, Jones ML, Clarke SJ, Baker JB, Warren JS, Factone JC. Effect of acute inflammatory lung injury on the expression of monocyte chemoattractant protein-I (MCP-1j in rat pulmonary alveolar macrophages. Am J Respir Cell Mol Biol 1992; 7: 134– 9. 41 Jiang J., Beller DI, Frendl G., Graves DT. Monocytes chemoattractant protein-l regulates adhesion molecule expression and cytokine production in human monocytes. J Immunol 1992; 148: 2423– 8. 42 Lin HS, Lokeshwar BL, Hsu S. Both granulocyte-macrophage CSF and macrophage CSF control the proliferation and survival of the same subset of alveolar macrophages. J Immunol 1989; 142: 515– 19. 43 Nakata K., Akagawa KS, Fukayama M., Hayashi Y., Kadokura M., Tokunaga T. Granulocyte-macrophage colony stimulating factor promotes the proliferation of human alveolar macrophages in vitro. J Immunol 1991; 147: 1266– 72. 44 Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068– 2101. 45 Thornhill MH, Kyan-Aung U., Haskard DO. IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils. J Immunol 1990; 144: 3060– 5. 46 Verdergaal EME, Beekhuizen H., Blokland I., van Furth R. Increased adhesion of human monocytes to IL-4-stimulated human venous endothelial cells via CD11/ CD 18, and very late antigen-4 (VLA4)/vascular cell adhesion molecule-I (VCAM-1)-dependent mechanisms. Clin Exp Immunol 1993; 93: 292– 8. 47 Rollings BJ, Yoshimura T., Leonard EJ, Pober JS. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-l/JE. Am J Pathol 1990; 136: 1229– 33. 48 Luscinskas FW, Kansas GS, Ding H., et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta-I-integrins, and beta-2-integrins. J Cell Biol 1994; 125: 1417– 27. 49 Harmsen AG, Muggenburg BH. Burton-Snipes M, Bice DE. The role of macrophages in particle translocation from lungs to lymph nodes. Science 1985; 320: 1277– 80. 50 Bilyk N., Holt PG. The surface phenotypic characterization of lung macrophages in C3H/HeJJ mice. Immunology 1991; 74: 645– 51. 51 Hofman FM, Lopez D., Husmann L., Meyer PR, Taylor CR. Heterogeneity of macrophage subpopulations in human lymphoid tissue and peripheral blood. Cell Immunol 1984; 88: 61– 74. 52 Baumgartner I., Scheiner O., Holzinger C., et al. Expression of the VEP 13 antigen (CD16) on naive human alveolar macrophages and cultured blood monocytes. Immunobiology 1988; 177: 317– 26. 53 Poulter LW, Campbell DA, Munro C., Janossy G. Discrimination of human macrophages and dendritic cells by means of monoclonal antibodies. Scand J Immunol 1986; 24: 351– 7. 54 Spiteri MA, Clarke SW, Poulter LW. Phenotypic and functional changes in alveolar macrophages contribute to the pathogenesis of sarcoidosis. Clin Exp Immunol 1988; 74: 359– 64. 55 Spiteri MA, Clarke SW, Poulter LW. Isolation of pheno-typically and functionally distinct macrophage subpopulations from human bronchoalveolar lavage. Eiur Respir J 1992; 5: 717– 26. 56 Spiteri MA, Clarke SW, Poulter LW. Alveolar macrophages that suppress T cell responses may be crucial to the pathogenetic outcome of pulmonary sarcoidosis. Eur Respir J 1992; 5: 394– 403. 57 Burke C., Power CK, Norris A., Condez A., Schmekel B., Poulter LW. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. Eur Respir J 1992; 5: 73– 9. 58 Plebanski M., Elson CJ, Billington WD. Dependency on interleukin-1 of primary human in vitro T-cell responses to soluble antigens. Eur J Immunol 1992; 22: 2353– 8. 59 Rotteveel FTM, Verhoef MHAM, Derijk R., van den Bergh H., Wovers DAW, Berkenbosch F. Both interleukin-alpha and interleukin-beta are involved as accessory signals in primary antigen (tetanus toxoid) induced T-.cell activation. Cell Immunol 1991; 138: 245– 50. 60 Holt PG. Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages. Clin Exp Immunol 1986; 63: 261– 70. 61 Lipscomp MF, Lyons CR, Nunez G., et al. Human alveolar macrophages: HLA-DR-positive macrophages that are poor stimulators of primary mixed leukocyte reaction. J Immunol 1986; 136: 497– 504. 62 Ettensohn DB, Lalor PA, Roberts NJ Jr. Human alveolar macrophage regulation of lymphocyte proliferation. Am Rev Respir Dis 1986; 133: 1091– 6. 63 Chelen CJ, Fang Y., Freeman GJ, et al. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. J Clin Invest 1995; 95: 1415– 21. 64 Holt PG, Oliver J., Bilyk N., et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 1993; 177: 397– 407. 65 Holt PG, Schon-Hegard MA, Oliver J. MHC class II antigen-bearing dendritic cells in pulmonary tissue of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 1988; 167: 1262– 74. 66 Holt PG, Degebrodt A., O'Leary C., Krska K., Plozza T. T-cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages. Clin Exp Immunol 1985; 63: 586– 94. 67 Bilyk N., Holt PG. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony stimulating factor. J Exp Med 1993; 177: 1773– 7. 68 Holt PG. Immunoregulation of the allergic reaction in the respiratory tract. Eur Respir J 1996 (in press). 69 Thepen T., van Rooijen N., Kraal G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune responses in mice. J Exp Med 1989; 170: 499– 509. 70 Thepen T., McMenamin C., Girn B., Kraal G., Holt PG. Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen. Clin Exp Allergy 1992; 22: 1107– 14. 71 Thepen T., McMenamin C., Oliver J., Kraal G., Holt PG. Regulation of immune responses to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance versus immunity. Eur J Immunol 1991; 21: 2845– 50. 72 Strickland DH, Thepen T., Kees UR, Kraal G., Holt PG. Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages. Immunology 1993; 80: 266– 72. 73 Pirron U., Schlunck T., Prim C., Rieber EP. IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE. Eur J Immunol 1990; 20: 1547– 51. 74 van der Heijden FL, van Neerven RJJ, van Katwijk M., Bos JD, Kapsenberg ML. Serum IgE-facilitated allergen presentation in atopic disease. J lmmunol 1993; 150: 3643– 50. 75 Bruijnzeel C., van Wichen DF, Toonstra J., Berrens L., Bruijnzeel PL. The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 1986; 278: 199– 205. 76 Barker JN, Alegre VA, MacDonald DM. Surface-bound immunoglobulin E on antigen-presenting cells in cutaneous tissue of atopic dermatitis. J Invest Dermatol 1988; 90: 117– 21. 77 Wang B., Rieger A., Kilgus O., et al. Epidermal Langerhans cells from human skin bind monomeric IgE via FcepsilonRI. J Exp Med 1992; 175: 1353– 65. 78 Bieber T., de la Salle H., Wollenberg A., et al. Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (FcepsilonRI). J Exp Med 1992; 175: 1285– 90. 79 Mudde GC, van Reijsen FC, Boland GJ, de Gast GC, Bruijnzeel PL, Bruijnzeel-Koomen CA. Allergen-presentation by epidermal Langerhans cells from patients with atopic dermatitis is mediated by IgE. Immunology 1990; 69: 335– 41. 80 Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantification, tissue distribution. J Exp Med 1973; 137: 1142– 7. 81 Hoefsmit ECM, Duijvestein AM, Kamperdijk EWA. Relation between Langerhans cells, veiled cells and interdi-gitating cells. Immunobiology 1982; 161: 255– 6. 82 Sertl K., Takemura T., Tschachler E., Ferrans VJ, Kaliner MA, Shevach EM. Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma. and visceral pleura. J Exp Med 1986; 163: 436– 51. 83 Soler P., Moreau A., Basset F., Hance AJ. Cigarette smoking induced changes in the number and differentiated state of pulmonary dendritic cells/Langerhans' cells. Am Rev Respir Dis 1989; 139: 1112– 17. 84 Nicod LP, Lipscomb MF, Weissler JC, Toews GB. Mononuclear cells from human lung parenchyma support antigen-induced T-lymphocyte proliferation. J Leukoc Biol 1989; 45: 336– 44. 85 Nicod LP, Lipscomb MF, Weissler JC, Lyons R., Albertson J., Toews GB. Mononuclear cells in human lung parenchyma. Characterization of a potent accessory cell not obtained by bronchoalveolar lavage. Am Rev Respir Dis 1987; 136: 818– 23. 86 Schon-Hegrad M., Oliver J., McMenamin C., Holt PG. Studies on the density distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (1a)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991; 173: 1345– 56. 87 van Haarst JMW, de Wit H., Drexhage HA, Hoogsteden HC. Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung. Am J Respir Cell Mol Biol 1994; 10: 487– 92. 88 Peters JH, Ruppert J., Gieseler RKH, Najar HM, Xu H. Differentiation of human monocytes into CD14 negative accessory cells; do dendritic cells derive from the monocyte lineage Pathobiology 1991; 59: 122– 6. 89 Holt PG, Schon-Hegrad MA, Philips MJ, McMenamin PG. Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy 1989; 19: 597– 601. 90 van Haarst JMW, Hoogsteden HC, de Wit HJ, Verhoeven GT, Havenith CEG, Drexhage HA. Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties. Am J Respir Cell Mol Biol 1994; 11: 344– 50. 91 Pugh CW, MacPherson GG, Steer HW. Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med 1983; 157: 1758– 63. 92 Knight SC, Farrant J., Bryant A., et al. Non-adherent, low-density cells from the human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 1986; 57: 595– 603. 93 Kraal G., Breel M., Janse M., Bruin G. Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J Exp Med 1986; 163: 981– 97. 94 Steinman RM, Witmer MD. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A 1978; 75: 5132– 40. 95 Inaba K., Metlay JP, Crowley MT, Steinman RM. Dendritic cells pulsed with antigens in vitro can prime antigen-specific, MHC restricted T cells in situ. J Exp Med 1990; 172: 631– 40. 96 Sornasse T., Flamand V., de Becker G., et al. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J Exp Med 1992; 175: 15– 21. 97 van Voorhuis WC, Hair LS, Steinman RM, Kaplan G. Human dendritic cells; enrichment and purification from peripheral blood. J Exp Med 1982; 155: 1172– 87. 98 Lin Gong J., McCarthy KM, Telford J., Tamatani T., Miyasaka M., Schneeberger EE. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J Exp Med 1992; 175: 797– 807. 99 Janeway CA, Bottomly K. Quantitative variation in la expression plays a central role in immune regulation. Immunol Today 1984; 5: 99– 105. 100 Holt PG, Haining S., Nelson DJ, Sedgwick JD. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 1994; 53: 256– 61. 101 McWilliam AS, Nelson D., Thomas JA, Holt PG. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J Exp Med 1994; 179: 1331– 6. 102 Nelson DJ, McMenamin C., McWilliam AS, Brenan M., Holt PG. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocom-patibility (1a)-negative precursors: differential regulation of la expression at different levels of the respiratory tract. J Exp Med 1994; 179: 203– 12. 103 Holt PG, Schon HM, Oliver J., Holt BJ, McMenamin PG. A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium. Int Arch Allergy Immunol 1990; 91: 155– 9. 104 van de Graaf EA, Out TA, Roos CM, Jansen HM. Respiratory membrane permeability and bronchial hyper-reactivity in patients with stable asthma: effects of therapy with inhaled steroids. Am Rev Respir Dis 1991; 143: 362– 8. 105 Richardson J., Bouchard T., Ferguson CC. Uptake and transport of exogenous proteins by respiratory epithelium. Lab Invest 1976; 35: 307– 14. 106 van de Graaf EA, Jansen HM, Weber JA, Koolen MGJ, Out TA. Influx of urea during bronchoalveolar lavage depends on the permeability of the respiratory membrane. Clin Chim Acta 1991; 196: 27– 40. 107 Herbert CA, King CM, Ring PC, et al. Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p I. Am J Respir Cell Mol Biol 1995; 12: 369– 78. 108 Martinez FD. Viral infections and the development of asthma. Am J Respir Crit Care Med 1995; 151: 1644– 8. 109 Gajewski TF, Joyce J., Fitch FW. Antiproliferative effect of interferon-gamma in immune regulation. III. Differential selection of THl and TH2 murine helper T lymphocyte clones using recombinant IL-2 and IFN-gamma. J Immunol 1989; 143: 15– 22. 110 Coffman RL, Chatelain R., Leal LMCC, Varkila K. Leishmania major infection in mice: a model system for the study of CD4+ T-cell subset differentiation [Review]. Res Immunol 1991; 142: 35– 40. 111 Kobayashi M., Fitz L., Ryan M., et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989; 170: 827– 31. 112 Chan SH, Perussia B., Gupta JW, et al. Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 1991; 173: 869– 79. 113 Romagnani S. Induction of Th1 and Th2 responses: a key role for the "natural"immune response Immunol Today 1992; 13: 379– 81. 114 Fiorentino DF, Zlotnik A., Mosmann TR, Howard M., O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815– 22. 115 Hsieh CS, Heimberger AB, Gold JS, O'Garra A., Murphy KM. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an α/β T-cell-receptor transgenic system. Proc Natl Acad Sci USA 1992; 89: 6065– 9. 116 Garside P., Mowat AN. Polarization of Th-cell responses: a phylogenetic consequence of nonspecific immune defence Immunol Today 1995; 16: 220– 3. 117 Bradding P., Feather IH, Wilson S., et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5 and IL-6 in human allergic mucosal inflammation. J Immunol 1993; 151: 3853– 6. 118 Snijdewint FGM, Kalinski P., Wierenga EA, Bos JD, Kapsenberg ML. Prostaglandin E, differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993; 150: 5321– 9. 119 Hilkens CMU, Vermeulen H., Wierenga EA, Kapsenberg ML. The differential modulation of T helper type-I (Th1) and type 2 (Th2) cytokine secretion by PGE, critically depends on interleukin-2. Eur J Immunol 1995; 25: 59– 63. 120 Hilkens CMU, Snijders A., Snijdewint FGM, Wierenga EA, Kapsenberg ML. Modulation of T-cell cytokine secretion by accessory cell-derived products. Eur Respir J 1996 (in press). 121 Nair S., Babu JS, Dunham RG, Kanda P., Burke RL, Rouse BT. Induction of primary antiviral cytotoxic, and proliferative response with antigens administered via dendritic cells. J Virol 1993; 67: 4062– 9. 122 McMenamin C., Holt PG. The natural immune response to inhaled soluble protein antigens involves major histo-compatibility complex (MHC) class I-restricted CD8 + T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of IgE production. J Exp Med 1993; 178: 889– 99. 123 Nobel A., Staynov DZ, Diaz-Sanchez D., Lee TH, Kemeny DM. Elimination of IgE regulatory rat CD8+ T cells in vivo increases the coordinate expression of Th2 cytokines IL-4, IL-5 and IL-10. Immunology 1993; 82: 326– 9. 124 Croft M., Carter L., Swain SL, Dutton RW. Generation of polarized antigen specific CD8+ effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994; 180: 1715– 28. 125 Weaver CT, Unanue ER. The costimulatory function of antigen presenting cells. Immunol Today 1990; 11: 49– 55. 126 Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71: 1065– 8. 127 Steinman RM. The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 1991; 9: 271– 96. 128 Galvin F., Freeman GJ, Razi-Wolf Z., et al. Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol 1992; 149: 3802– 8. 129 Young JW, Koulova L., Soergel SA, Clark EA, Steinman RM, Dupont B. The B7/BBI antigen provides one of the several costimulatory signals for the activation of CD4 + T lymphocytes by human blood dendritic cells in vitro. J Clin Invest 1992; 90: 229– 37. 130 Jenkins MK, Taylor PS, Norton SD, Urdahl KB. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 1991; 147: 2461– 6. 131 de Becker G., Sornasse T., Nabavi N., et al. Immuno-globulin isotype regulation by antigen-presenting cells in vivo. Eur J Immunol 1994; 24: 1523– 8. 132 Linsley PS, Greene JL, Tan P., et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 1992; 176: 1595– 1604. 133 Lenschow DJ, Zeng Y., Thistlethwaire JR, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4-Ig [Comment]. Science 1992; 257: 751. 134 Gilbert KM, Hoang KD, Weigle WO. Thl and Th2 clones differ in their response to a tolerogenic signal. J Immunol 1990; 144: 2063– 71. 135 McArthur JG, Raulet DH. CD28-induced costhulation of T helper type 2 cells mediated by induction of responsiveness to interleukin-4. J Exp Med 1993; 178: 1645– 53. 136 Barcy S., Wettendorff M., Leo O., et al. FcR cross-linking on monocytes results in impaired T cell stimulatory capacity. Int Immunol 1995; 7: 179– 89. 137 van Neerven RJJ. T lymphocyte responses to allergens: specificity and activation requirements. PhD thesis, University of Amsterdam, 1995. 138 Wilson AG, de Vries N., Pociot F., DiGiouiu FS, van der Putte LB, Duff GW. An allelic polymorphism within the human tumour necrosis factor alpha promoter region is strongly associated with HLA Al, B8, and DR3 alleles. J Exp Med 1993; 177: 557– 60. Citing Literature Volume51, Issue5May 1996Pages 279-292 ReferencesRelatedInformation
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