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Cerebral infarction as a result of tumor emboli

1987; Wiley; Volume: 60; Issue: 1 Linguagem: Inglês

10.1002/1097-0142(19870701)60

1097-0142

Brian Patrick O’Neill, Robert P. Dinapoli, Haruo Okazaki,

Cerebrovascular and Carotid Artery Diseases

CancerVolume 60, Issue 1 p. 90-95 ArticleFree Access Cerebral infarction as a result of tumor emboli B. P. O'Neill MD, Corresponding Author B. P. O'Neill MD Department of Neurology, Mayo Clinic and Foundation, Rochester, MinnesotaDepartment of Neurology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905===Search for more papers by this authorRobert P. Dinapoli MD, Robert P. Dinapoli MD Department of Neurology, Mayo Clinic and Foundation, Rochester, MinnesotaSearch for more papers by this authorHaruo Okazaki MD, Haruo Okazaki MD Department of Pathology, Mayo Clinic and Foundation, Rochester, MinnesotaSearch for more papers by this author B. P. O'Neill MD, Corresponding Author B. P. O'Neill MD Department of Neurology, Mayo Clinic and Foundation, Rochester, MinnesotaDepartment of Neurology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905===Search for more papers by this authorRobert P. Dinapoli MD, Robert P. Dinapoli MD Department of Neurology, Mayo Clinic and Foundation, Rochester, MinnesotaSearch for more papers by this authorHaruo Okazaki MD, Haruo Okazaki MD Department of Pathology, Mayo Clinic and Foundation, Rochester, MinnesotaSearch for more papers by this author First published: 1 July 1987 https://doi.org/10.1002/1097-0142(19870701)60:1 3.0.CO;2-CCitations: 44AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Autopsy records at Mayo Clinic were reviewed to determine the pattern of cerebral infarction occurring as a consequence of nonmyxomatous tumor emboli. Between 1951 and 1984, there were seven adult patients who fulfilled the criteria: (1) focal or multifocal neurologic disease of abrupt onset; (2) systemic cancer; and (3) pathologic demonstration of tumor emboli in appropriate vessels. Tumors originated from the lung in four patients and from the colon and hypopharynx in one each; in one patient the primary source was unknown. Five patients had carotid and two had vertebrobasilar system strokes. Two patients had at least one antecedent transient ischemic attack (TIA). Three patients presented with cerebral infarction as the initial manifestation of their cancer. In two patients, it occurred immediately after pneumonectomy. In four patients, cerebral infarction occurred in a setting of widespread systemic, including pulmonary, metastases. At postmortem examination, one patient had a single large basilar artery tumor embolus. The others had multiple large and small vessel tumor embolic occlusions. The anterior circulation was affected in three patients, the posterior circulation in two, and both circulations were affected in two. Four patients had additional brain parenchymal metastases including one with diffuse leptomeningeal spread. References 1 Posner JB. Neurologic complications of systemic cancer. DM 1978; 24: 1– 60. 2 Collins RC, Al-Mondhiry H, Chernik NL, Poser JB. Neurologic manifestations of intravascular coagulation in patients with cancer. Neurology 1975; 25: 795– 806. 3 Reagan TJ, Okazaki H. The thrombotic syndrome associated with carcinoma. Arch Neurol 1974; 31: 390– 395. 4 Mahar LJ, Lie JT, Groover RV, Seward JB, Puga FJ, Feldt RH. Primary cardiac myxosarcoma in a child. 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