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BIBTEX RIS

Titration of serum anti-ganglioside antibodies in patients with chronic medular injury previous to treatment with GM1 ganglioside

2003; Brazilian Society of Orthopedics and Traumatology; Volume: 11; Issue: 2 Linguagem: Inglês

10.1590/s1413-78522003000200001

ISSN

2176-7521

Autores

Tarcísio Eloy Pessoa de Barros Filho, Ciro da Silva Filho,

Tópico(s)

Cerebral Palsy and Movement Disorders

Resumo

Anti-ganglioside serum titers were evaluated by ELISA in 150 patients with complete spinal cord lesion for 6 to 12 months (IgG monosialo GM1, IgM monosialo GM1, IgG asialo GM1, IgM asialo GM1, IgG disialo GD1b e IgM disialo GD1b) prior to treatment with GM1 100 mg/day i.m. Only 4 patients showed positive titers for anti-asialo-GM1 (IgM) antibodies . All patients were clinically examined during and after treatment. No important side effects were observed with GM1 therapy. These results suggest that GM1-ganglioside administration in patients with chronic spinal cord injury is safe.

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